International Review of Ophthalmology ›› 2024, Vol. 48 ›› Issue (2): 123-128.doi: 10.3760/ cma.j.issn.1673-5803.2024.02.008

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The relationship between inwardly rectifying potassium channels and retinopathy

Li Lian1, Yang Xu2, Xu Ying3, Ma Hongjie1   

  1. 1 Aier Eye Hospital, Jinan University, Guangzhou 510071, China;2 Aier Eye Institute, Changsha 410000, China; 3 Guangdong-Hongkong-Macau Institute of CNS Regeneration, Key Laboratory of CNS Regeneration (Ministry of Education), Jinan University, Guangzhou 510632, China
  • Online:2024-04-22 Published:2024-04-22
  • Contact: Ma Hongjie, Email: eyemhj@163.com
  • Supported by:
    Key Laboratory of CNS Regeneration (Jinan University) Open Fund 2021

Abstract: Inwardly rectifying potassium (Kir) channels, a subclass within the potassium channel family, are extensively distributed in a variety of tissue cells and play a vital role in maintaining bodily homeostasis. Recent research indicates their presence in the retinal pigment epithelium, neurons, glial cells, and vascular cells. These channels are instrumental in preserving retinal osmotic balance, combating neurotoxic and oxidative stress, and facilitating visual processing. Kir channels have been implicated in the progression of several retinal diseases, including diabetic retinopathy, hereditary KCNJ13-related retinal disorders, and glaucoma. (Int Rev Ophthalmol, 2024, 48: 123-128)

Key words: inwardly rectifying potassium channel protein, retinal diseases